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Teacher(s)

Elens Laure; Haufroid Vincent; Hermans Emmanuel (coordinator);

Language

French

Prerequisites

The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.

Content

1. Introduction and general pharmacodynamics
Mechanisms of action of drugs
Types of receptors/targets
Relationships between receptor binding and pharmacological response
Variability of individual response
Large therapeutic classes
2. Pharmacokinetics.
Reminder of the main concepts (compliance, absorption, distribution, metabolism and excretion)
Description of the main physiological causes of inter-individual pharmacokinetic variability (Age [children, elderly], Pregnancy, Genetic polymorphisms, Drug and environmental interactions...)
Description of the main pathological causes of inter-individual pharmacokinetic variability (Renal function, Liver function, Obesity, Evolution of the disease...)
3. Toxicology
Basic concepts in toxicology: exposure, dose, danger, risk
Factors determining the toxic response to a xenobiotic
Main mechanisms of toxicity
Antidote concept

Teaching methods

Presentation in lectures of concepts, principles and processes with illustrations from concrete examples of drugs commonly used in human medicine.

Evaluation methods

Written exam that may include multiple-choice questions with reasoning and open-ended and/or short-answer questions.
The student must demonstrate mastery of his knowledge and understanding of the concepts.
As far as possible, the number of questions or their importance will take care to reflect the importance and or the hourly volumes of each of the parties. The final mark will take into consideration a weighting of the results of each part. Note: for students who do not have the Toxicology part (WMDS1237D), the final mark combines the marks of the Pharmacodynamics and Pharmacokinetics parts in an equivalent way.
Any overall average below 10/20 is rounded down.
The type of assessment chosen during the 1st exam session may be subject to change depending on the number of students registered for the second session.

Online resources

Most of the documents projected during the course are available on the Moodle platform. Reference books are suggested at the start of each part of the course.

Bibliography

Goodman and Gilman's Pharmacological Basis of Therapeutics, Twelfth Edition, 2010
Casarett and Doull's Toxicology - The basic science of poisons, 9th Edition, 2019
Urs A. Boelsterli - Mechanistic Toxicology: The molecular basis of how chemicals disrupt biological targets, 2nd Edition, 2007

Teaching materials

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Faculty or entity

MED