LDRI
Avenue Mounier 72/B1.72.01
1200 Woluwe-Saint-Lambert
Giulio Muccioli
Professeur ordinaire
- پô
Բé Label Institution 1998 Candidat en sciences pharmaceutiques Сư洫ý 2001 Pharmacien Сư洫ý 2003 Diplômé d'éٳܻ approfondies en sciences de la santé Сư洫ý 2005 Docteur en sciences pharmaceutiques Сư洫ý
- Les cours
Nom ID Conception du médicament WFARM1008 Introduction à la chimie analytique WFARM1243 Travaux pratiques d'introduction à la chimie analytique WFARM1244 Stage d'immersion professionnelle dans le monde pharmaceutique WFARM1309 Analyse instrumentale appliquée aux sciences pharmaceutiques WFARM1312 Travaux pratiques d'analyse instrumentale WFARM1313 Compléments d'analyse instrumentale WFARM1329 Séminaire intégré en sciences pharmaceutiques WFARM1349 Analyse et contrôle de qualité des médicaments WFARM2117 Chimie médicinale WFARM2118 Séminaires et travaux pratiques d'intégration en sciences pharmaceutiques WFARM2135 Etude critique d'un article de recherche en sciences pharmaceutiques WFARM2175 Présentation d'un travail de recherche en sciences pharmaceutiques WFARM2176 Séminaire d'intégration pharmaceutique (finalité approfondie) WFARM2249 Séminaire d'intégration pharmaceutique (finalité spécialisée) WFARM2259 Analyse des médicaments issus des biotechnologies WFARM2266 Exercice de communication scientifique WFARM2275 Chimie pharmaceutique avancée et drug design WFARM2501 Isolement et analyse structurale de produits naturels WFARM2508 Analyse instrumentale biomédicale et radioprotection WSBIM1200
Responsable du "Bioanalysis and Pharmacology of Bioactive Lipids Research Group" (BPBL lab)
Gillard, Justine ; Roumain, Martin ; Picalausa, Corinne ; Thibaut, Morgane ; Clerbaux, Laure-Alix ; Tailleux, Anne ; Staels, Bart ; Muccioli, Giulio ; Bindels, Laure B. ; Leclercq, Isabelle. A gut microbiota-independent mechanism shapes the bile acid pool in mice with MASH. In: JHEP Reports, Vol. 6, no. 11, p. 101148 [1-11] (2024). doi:10.1016/j.jhepr.2024.101148 (Accepté/Sous presse).
Marotti, Valentina ; Xu, Yiqing ; Bohns Michalowski, Cecilia ; Zhang, Wunan ; Ladeiro Domingues, Inês ; Ameraoui, Hafsa ; Moreels, Tom ; Baatsen, Pieter ; Van Hul, Matthias ; Muccioli, Giulio ; Cani, Patrice D. ; Al Houayek, Mireille ; Malfanti, Alessio ; Beloqui Garcia, Ana. A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment. In: Bioactive Materials, Vol. 32, p. 206-221 (2024). doi:10.1016/j.bioactmat.2023.09.014.
Muccioli, Giulio ; Bannenberg, Gerard. Editorial – Special issue of the 8th European Workshop on Lipid Mediators. In: Prostaglandins & Other Lipid Mediators, Vol. 172, no., p. 106835 (2024). doi:10.1016/j.prostaglandins.2024.106835.
Paone, Paola ; Latousakis, Dimitris ; Terrasi, Romano ; Vertommen, Didier ; Jian, Ching ; Borlandelli, Valentina ; Suriano, Francesco ; Johansson, Malin E V ; Puel, Anthony ; Bouzin, Caroline ; Delzenne, Nathalie M. ; Salonen, Anne ; Juge, Nathalie ; Florea, Bogdan I ; Muccioli, Giulio ; Overkleeft, Herman ; Van Hul, Matthias ; Cani, Patrice D.. Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.. In: Gut, Vol. X, no.1, p. 18 (2024). doi:10.1136/gutjnl-2023-330301.
Mwema, Ariane ; Gratpain, Viridiane ; Ucakar, Bernard ; Vanvarenberg, Kevin ; Perdaens, Océane ; Van Pesch, Vincent ; Muccioli, Giulio ; des Rieux, Anne. Impact of calcitriol and PGD2-G-loaded lipid nanocapsules on oligodendrocyte progenitor cell differentiation and remyelination. In: Drug Delivery and Translational Research, (2024). doi:10.1007/s13346-024-01535-8.
Gratpain, Viridiane ; Loriot, Axelle ; Bottemanne, Pauline ; d'Auria, Ludovic ; Terrasi, Romano ; Payen, Valéry L ; Van Pesch, Vincent ; Muccioli, Giulio ; des Rieux, Anne. Influence of a pro-inflammatory stimulus on the miRNA and lipid content of human dental stem cell-derived extracellular vesicles and their impact on microglial activation.. In: Heliyon, Vol. 10, no.5, p. e27025 (2024). doi:10.1016/j.heliyon.2024.e27025.
Labrak, Y ; Al Houayek, Mireille ; Mwema, Ariane ; d'Auria, L ; Ucakar, Bernard ; Van Pesch, Vincent ; Muccioli, Giulio ; des Rieux, Anne. The combined administration of LNC-encapsulated retinoic acid and calcitriol stimulates oligodendrocyte progenitor cell differentiation in vitro and in vivo after intranasal administration.. In: International journal of pharmaceutics, Vol. 659, p. 124237 (2024). doi:10.1016/j.ijpharm.2024.124237 (Accepté/Sous presse).
Romano, Adele ; Friuli, Marzia ; Eramo, Barbara ; Gallelli, Cristina Anna ; Koczwara, Justyna Barbara ; Azari, Elnaz Karimian ; Paquot, Adrien ; Arnold, Myrtha ; Langhans, Wolfgang ; Muccioli, Giulio ; Lutz, Thomas Alexander ; Gaetani, Silvana. "To brain or not to brain": evaluating the possible direct effects of the satiety factor oleoylethanolamide in the central nervous system.. In: Frontiers in endocrinology, Vol. 14, p. 1158287 [1-12] (2023). doi:10.3389/fendo.2023.1158287.
van Dijk, Myrthe J ; van Oirschot, Brigitte A ; Harrison, Alexander N ; Recktenwald, Steffen M ; Qiao, Min ; Stommen, Amaury ; Cloos, Anne-Sophie ; Vanderroost, Juliette ; Terrasi, Romano ; Dey, Kuntal ; Bos, Jennifer ; Rab, Minke A E ; Bogdanova, Anna ; Minetti, Giampaolo ; Muccioli, Giulio ; Tyteca, Donatienne ; Egée, Stéphane ; Kaestner, Lars ; Molday, Robert S ; van Beers, Eduard J ; van Wijk, Richard. A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia.. In: American journal of hematology, Vol. 98, no. 12, p. 1877-1887 (2023). doi:10.1002/ajh.27088.
Moens de Hase, Emilie ; Petitfils, Camille ; Al Houayek, Mireille ; Depommier, Clara ; Le Faouder, Pauline ; Delzenne, Nathalie M. ; Van Hul, Matthias ; Muccioli, Giulio ; Cenac, Nicolas ; Cani, Patrice D.. Dysosmobacter welbionis effects on glucose, lipid, and energy metabolism are associated with specific bioactive lipids. In: Journal of lipid research, Vol. 64, no. 10, p. 100437 [1-14] (2023). doi:10.1016/j.jlr.2023.100437.
Ruiz, Florian ; Peter, Benjamin ; Rebeaud, Jessica ; Vigne, Solenne ; Bressoud, Valentine ; Roumain, Martin ; Wyss, Tania ; Yersin, Yannick ; Wagner, Ingrid ; Kreutzfeldt, Mario ; Pimentel Mendes, Marisa ; Kowalski, Camille ; Boivin, Gael ; Roth, Leonard ; Schwaninger, Markus ; Merkler, Doron ; Muccioli, Giulio ; Hugues, Stephanie ; Petrova, Tatiana V ; Pot, Caroline. Endothelial cell-derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis.. In: EMBO reports, Vol. 24, no.3, p. e55328 [1-20] (2023). doi:10.15252/embr.202255328.
Hoste, Emilia ; Paquot, Adrien ; Panin, Nadtha ; Horion, Shaleena ; El-Hamdaoui, Halima ; Muccioli, Giulio ; Haufroid, Vincent ; Elens, Laure. Genetic polymorphisms in SLCO2B1 and ABCC1 conjointly modulate atorvastatin intracellular accumulation in HEK293 recombinant cell lines. In: Therapeutic drug monitoring, Vol. 45, no. 3, p. 400-408 (2023). doi:10.21203/rs.3.rs-1520877/v1 (Accepté/Sous presse).
Roumain, Martin ; Guillemot-Legris, Owein ; Ameraoui, Hafsa ; Al Houayek, Mireille ; Muccioli, Giulio. Identification and in vivo detection of side-chain hydroxylated metabolites of 4β-hydroxycholesterol. In: The Journal of Steroid Biochemistry and Molecular Biology, Vol. 234, p. 106376 (2023). doi:10.1016/j.jsbmb.2023.106376.
Mwema, Ariane ; Muccioli, Giulio ; des Rieux, Anne. Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis.. In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 364, p. 435-457 (2023). doi:10.1016/j.jconrel.2023.10.052.
Régnier, Marion ; Van Hul, Matthias ; Roumain, Martin ; Paquot, Adrien ; de Wouters d’Oplinter, Alice ; Suriano, Francesco ; Everard, Amandine ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Cani, Patrice D.. Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota. In: Gut Microbes, Vol. 15, no.1, p. 20 (2023). doi:10.1080/19490976.2023.2178796.
Mwema, Ariane ; Bottemanne, Pauline ; Paquot, Adrien ; Ucakar, Bernard ; Vanvarenberg, Kevin ; Al Houayek, Mireille ; Muccioli, Giulio ; des Rieux, Anne. Lipid nanocapsules for the nose-to-brain delivery of the anti-inflammatory bioactive lipid PGD-G.. In: Nanomedicine : nanotechnology, biology, and medicine, Vol. 48, p. 102633 (2023). doi:10.1016/j.nano.2022.102633.
Karemera, Manon ; Verce, Marko ; Roumain, Martin ; Muccioli, Giulio ; Cani, Patrice D. ; Everard, Amandine ; Stéphenne, Xavier ; Sokal, Etienne. Pediatric Autoimmune or Primary Sclerosing Cholangitis: Metronidazole Effectiveness on Biochemical Data, Bile Acid Profile, and Gut Microbiota: A Pilot Study. In: JPGN reports, Vol. 4, no. 3, p. e334 [1-8] (2023). doi:10.1097/pg9.0000000000000334.
Cloos, Anne-Sophie ; Rab, Minke AE ; Van Der Smissen, Patrick ; van Oirschot, Brigitte A ; Mignolet, Eric ; van der Net, Jeroen B ; Koster, Ad ; Kleinen, Kelly ; Larondelle, Yvan ; Terrasi, Romano ; Muccioli, Giulio ; van Wijk, Richard ; Tyteca, Donatienne. Red blood cells from patients with sitosterolemia exhibit impaired membrane lipid composition and distribution and decreased deformability. In: Frontiers in Hematology. Red Cells, Iron and Erythropoiesis, Vol. 2, p. 055086 [1-14] (2023). doi:10.3389/frhem.2023.1055086.
van Doorslaer de ten Ryen, Sophie ; Dalle, Sebastiaan ; Terrasi, Romano ; Koppo, Katrien ; Muccioli, Giulio ; Deldicque, Louise. Regulation of the endocannabinoid system by endurance and resistance exercise in hypoxia in human skeletal muscle.. In: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 134, no.3, p. 569-580 (2023). doi:10.1152/japplphysiol.00645.2022.
Paquot, Adrien ; Bestard-Escalas, Juan ; Muccioli, Giulio. Set up and validation of a sensitive method to quantify prostaglandins, prostaglandin-glycerol esters and prostaglandin-ethanolamides, as well as their respective precursors.. In: Prostaglandins & other lipid mediators, , p. 106763 (2023). doi:10.1016/j.prostaglandins.2023.106763 (Accepté/Sous presse).
Abdul Khaliq, Hafiz ; Al Houayek, Mireille ; Quetin-Leclercq, Joëlle ; Muccioli, Giulio. 5'AMP-activated protein kinase: an emerging target of phytochemicals to treat chronic inflammatory diseases.. In: Critical reviews in food science and nutrition, , p. [1-26] (2022). doi:10.1080/10408398.2022.2145264 (Accepté/Sous presse).
Ranaivo, Harimalala ; Zhang, Zhengxiao ; Alligier, Maud ; Van Den Berghe, Laurie ; Sothier, Monique ; Lambert-Porcheron, Stéphanie ; Feugier, Nathalie ; Cuerq, Charlotte ; Machon, Christelle ; Neyrinck, Audrey M. ; Seethaler, Benjamin ; Rodriguez, Julie ; Roumain, Martin ; Muccioli, Giulio ; Maquet, Véronique ; Laville, Martine ; Bischoff, Stephan C ; Walter, Jens ; Delzenne, Nathalie M. ; Nazare, Julie-Anne. Chitin-glucan supplementation improved postprandial metabolism and altered gut microbiota in subjects at cardiometabolic risk in a randomized trial.. In: Scientific reports, Vol. 12, no.1, p. 8830 [1-14] (2022). doi:10.1038/s41598-022-12920-z.
Mozaheb, Negar ; Van Der Smissen, Patrick ; Opsomer, Tomas ; Mignolet, Eric ; Terrasi, Romano ; Paquot, Adrien ; Larondelle, Yvan ; Dehaen, Wim ; Muccioli, Giulio ; Mingeot-Leclercq, Marie-Paule. Contribution of Membrane Vesicle to Reprogramming of Bacterial Membrane Fluidity in Pseudomonas aeruginosa.. In: mSphere, Vol. 7, no. 3, p. e0018722 [1-13] (2022). doi:10.1128/msphere.00187-22.
Abdul Khaliq, Hafiz ; Ortiz Aguirre, Sergio Enrique ; Al Houayek, Mireille ; Muccioli, Giulio ; Quetin-Leclercq, Joëlle. Dereplication and Quantification of Major Compounds of L. Extracts and Assessment of Their Effect on LPS-Activated J774 Macrophages.. In: Molecules (Basel, Switzerland), Vol. 27, no.3, p. 963 [1-19] (2022). doi:10.3390/molecules27030963.
Bozzato, Elia ; Tsakiris, Nikolaos ; Paquot, Adrien ; Muccioli, Giulio ; Bastiancich, Chiara ; Préat, Véronique. Dual-drug loaded nanomedicine hydrogel as a therapeutic platform to target both residual glioblastoma and glioma stem cells.. In: International journal of pharmaceutics, Vol. 628, p. 122341 [1-12] (2022). doi:10.1016/j.ijpharm.2022.122341.
Le Roy, Tiphaine ; Moens De Hase, Emilie ; Van Hul, Matthias ; Paquot, Adrien ; Pelicaen, Rudy ; Régnier, Marion ; Depommier, Clara ; Druart, Céline ; Everard, Amandine ; Maiter, Dominique ; Delzenne, Nathalie M. ; Bindels, Laure B. ; de Barsy, Marie ; Loumaye, Audrey ; Hermans, Michel ; Thissen, Jean-Paul ; Vieira-Silva, Sara ; Falony, Gwen ; Raes, Jeroen ; Muccioli, Giulio ; Cani, Patrice D.. Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice. In: Gut, Vol. 71, p. 534–543 (2022). doi:10.1136/gutjnl-2020-323778.
Copperi, Francesca ; Schleis, Inna ; Roumain, Martin ; Muccioli, Giulio ; Casola, Stefano ; Klingenspor, Martin ; Pfeifer, Alexander ; Gnad, Thorsten. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.. In: Communications biology, Vol. 5, no.1, p. 280 [1-9] (2022). doi:10.1038/s42003-022-03201-6.
Abdul Khaliq, Hafiz ; Ortiz Aguirre, Sergio Enrique ; Al Houayek, Mireille ; Neyts, Tanguy ; Muccioli, Giulio ; Quetin-Leclercq, Joëlle. Effect of a methanolic extract of Salvadora oleoides Decne. on LPS-activated J774 macrophages, its in vitro and in vivo toxicity study and dereplication of its chemical constituents. In: Toxicology Reports, Vol. 9, p. 1742-1753 (2022). doi:10.1016/j.toxrep.2022.09.004.
Barington, Line ; Christensen, Liv von Voss ; Pedersen, Kristian Kåber ; Niss Arfelt, Kristine ; Roumain, Martin ; Jensen, Kristian Høj Reveles ; Kjær, Viktoria Madeline Skovgaard ; Daugvilaite, Viktorija ; Kearney, John F ; Christensen, Jan Pravsgaard ; Hjortø, Gertrud Malene ; Muccioli, Giulio ; Holst, Peter Johannes ; Rosenkilde, Mette Marie. GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity.. In: Cells, Vol. 11, no.3, p. 494 [1-18] (2022). doi:10.3390/cells11030494.
Berland, Chloé ; Castel, Julien ; Terrasi, Romano ; Montalban, Enrica ; Foppen, Ewout ; Martin, Claire ; Muccioli, Giulio ; Luquet, Serge ; Gangarossa, Giuseppe. Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis.. In: Molecular psychiatry, Vol. 27, no.4, p. 2340-2354 (2022). doi:10.1038/s41380-021-01428-z.
Labrak, Yasmine ; Heurtault, Béatrice ; Frisch, Benoît ; Saulnier, Patrick ; Lepeltier, Elise ; Miron, Veronique E ; Muccioli, Giulio ; des Rieux, Anne. Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells.. In: International journal of pharmaceutics, Vol. 618, p. 121623 (2022). doi:10.1016/j.ijpharm.2022.121623.
Valderrama, Jaime A. ; Pérez-Herrera, Andrea ; Muccioli, Giulio ; Venegas-Casanova, Edmundo A. ; Jara-Aguilar, Rafael ; Calderon, Pedro Buc ; Benites, Julio ; Mitu, Liviu. On the Reaction of 2-Alkanoylnaphthohydroquinones with Hydroxylamine: Access to Cytotoxic 2-(Hydroxyamino)-1,4-naphthoquinone and Their 3-(Hydroxyimino)alkyl Analogous. In: Journal of Chemistry, Vol. 2022, p. 1-8 (2022). doi:10.1155/2022/7664037.
De Berdt, Pauline ; Vanvarenberg, Kevin ; Ucakar, Bernard ; Bouzin, Caroline ; Paquot, Adrien ; Gratpain, Viridiane ; Loriot, Axelle ; Payen, Valery ; Bearzatto, Bertrand ; Muccioli, Giulio ; Gatto, Laurent ; Diogenes, A ; des Rieux, Anne. The human dental apical papilla promotes spinal cord repair through a paracrine mechanism.. In: Cellular and molecular life sciences : CMLS, Vol. 79, no.5, p. 252 (2022). doi:10.1007/s00018-022-04210-8.
Yelek, Caner ; Mignion, Lionel ; Paquot, Adrien ; Bouzin, Caroline ; Corbet, Cyril ; Muccioli, Giulio ; Cani, Patrice D. ; Jordan, Bénédicte. Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer. In: Cancers, Vol. 14, no. 3, p. 562 [1-16] (2022). doi:10.3390/cancers14030562.
Bottemanne, Pauline ; Paquot, Adrien ; Ameraoui, Hafsa ; Guillemot-Legris, Owein ; Al Houayek, Mireille ; Muccioli, Giulio. 25-Hydroxycholesterol metabolism is altered by lung inflammation, and its local administration modulates lung inflammation in mice.. In: FASEB journal, Vol. 35, no.4, p. e21514 [1-19] (2021). doi:10.1096/fj.202002555R.
Stillemans, Gabriel ; Paquot, Adrien ; Muccioli, Giulio ; Hoste, Emilia ; Panin, Nadtha ; Åsberg, Anders ; Balligand, Jean-Luc ; Haufroid, Vincent ; Elens, Laure. Atorvastatin population pharmacokinetics in a real‐life setting: Influence of genetic polymorphisms and association with clinical response. In: Clinical and Translational Science, (2021). doi:10.1111/cts.13185.
Thibaut, Morgane ; Gillard, Justine ; Dolly, Adeline ; Roumain, Martin ; Leclercq, Isabelle ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Bindels, Laure B.. Bile Acid Dysregulation Is Intrinsically Related to Cachexia in Tumor-Bearing Mice. In: Cancers, Vol. 13, no.24, p. 6389 [1-17] (2021). doi:10.3390/cancers13246389.
Al Houayek, Mireille ; Ameraoui, Hafsa ; Muccioli, Giulio. Bioactive lipids in inflammatory bowel diseases - From pathophysiological alterations to therapeutic opportunities.. In: Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol. 1866, no.2, p. 158854 [1-18] (2021). doi:10.1016/j.bbalip.2020.158854.
Ange, Marine ; De Poortere, Julien ; Ginion, Audrey ; Battault, Sylvain ; Dechamps, Mélanie ; Muccioli, Giulio ; Roumain, Martin ; Morelle, Johann ; Druart, Sébastien ; Mathivet, Thomas ; Bertrand, Luc ; Castanares Zapatero, Diego ; Horman, Sandrine ; Beauloye, Christophe. Canagliflozin protects against sepsis capillary leak syndrome by activating endothelial α1AMPK.. In: Scientific reports, Vol. 11, no. 1, p. 13700 [1-13] (2021). doi:10.1038/s41598-021-93156-1.
Van Den Brûle, Sybille ; Rappe, Margaux ; Ambroise, Jérôme ; Bouzin, Caroline ; Dessy, Chantal ; Paquot, Adrien ; Muccioli, Giulio ; Lison, Dominique. Diesel exhaust particles alter the profile and function of the gut microbiota upon subchronic oral administration in mice.. In: Particle and fibre toxicology, Vol. 18, no. 1, p. 7 [1-15] (2021). doi:10.1186/s12989-021-00400-7.
Perez, Laeticia ; Scarcello, Eleonora ; Ibouraadaten, Saloua ; Yakoub, Yousof ; Leinardi, Riccardo ; Ambroise, Jérôme ; Bearzatto, Bertrand ; Gala, Jean-Luc ; Paquot, Adrien ; Muccioli, Giulio ; Bouzin, Caroline ; Van Den Brûle, Sybille ; Lison, Dominique. Dietary nanoparticles alter the composition and function of the gut microbiota in mice at dose levels relevant for human exposure.. In: Food and chemical toxicology, Vol. 154, p. 112352 [1-13] (2021). doi:10.1016/j.fct.2021.112352.
Buisseret, Baptiste ; Guillemot-Legris, Owein ; Ben Kouidar, Youssef ; Paquot, Adrien ; Muccioli, Giulio ; Al Houayek, Mireille. Effects of R-flurbiprofen and the oxygenated metabolites of endocannabinoids in inflammatory pain mice models.. In: The FASEB Journal, Vol. 35, no. 4, p. e21411 [1-16] (2021). doi:10.1096/fj.202002468R.
Gratpain, Viridiane ; Mwema, Ariane ; Labrak, Yasmine ; Muccioli, Giulio ; Van Pesch, Vincent ; des Rieux, Anne. Extracellular vesicles for the treatment of central nervous system diseasesExtracellular vesicles for the treatment of central nervous system diseases. In: Advanced drug delivery reviews, Vol. 174, p. 535-552 (2021). doi:10.1016/j.addr.2021.05.006.
Genton, Laurence ; Pruijm, Menno ; Teta, Daniel ; Bassi, Isabelle ; Cani, Patrice D. ; Gaïa, Nadia ; Herrmann, François R ; Marangon, Nicola ; Mareschal, Julie ; Muccioli, Giulio ; Stoermann, Catherine ; Suriano, Francesco ; Wurzner-Ghajarzadeh, Arlene ; Lazarevic, Vladimir ; Schrenzel, Jacques. Gut barrier and microbiota changes with glycine and branched-chain amino acid supplementation in chronic haemodialysis patients.. In: Journal of cachexia, sarcopenia and muscle, , p. [1-13] (2021). doi:10.1002/jcsm.12781 (Accepté/Sous presse).
Abot, Anne ; Wemelle, Eve ; Laurens, Claire ; Paquot, Adrien ; Pomie, Nicolas ; Carper, Deborah ; Bessac, Arnaud ; Mas Orea, Xavier ; Fremez, Christophe ; Fontanie, Maxime ; Lucas, Alexandre ; Lesage, Jean ; Everard, Amandine ; Meunier, Etienne ; Dietrich, Gilles ; Muccioli, Giulio ; Moro, Cedric ; Cani, Patrice D. ; Knauf, Claude. Identification of new enterosynes using prebiotics: roles of bioactive lipids and mu-opioid receptor signalling in humans and mice.. In: Gut, Vol. 70, no. 6, p. 1078-1087 (2021). doi:10.1136/gutjnl-2019-320230.
Cloos, Anne-Sophie ; Daenen, Laura G. M. ; Maja, Mauriane ; Stommen, Amaury ; Vanderroost, Juliette ; Van Der Smissen, Patrick ; Rab, Minke ; Westerink, Jan ; Mignolet, Eric ; Larondelle, Yvan ; Terrasi, Romano ; Muccioli, Giulio ; Dumitru, Andra-Cristina ; Alsteens, David ; van Wijk, Richard ; Tyteca, Donatienne. Impaired Cytoskeletal and Membrane Biophysical Properties of Acanthocytes in Hypobetalipoproteinemia – A Case Study. In: Frontiers in Physiology, Vol. 12, no. 2, p. 638027 [1-22] (2021). doi:10.3389/fphys.2021.638027.
Thibaut, Morgane ; Sboarina, Martina ; Roumain, Martin ; Pötgens, Sarah ; Neyrinck, Audrey M. ; Destrée, Florence ; Gillard, Justine ; Leclercq, Isabelle ; Dachy, Guillaume ; Demoulin, Jean-Baptiste ; Tailleux, Anne ; Lestavel, Sophie ; Rastelli, Marialetizia ; Everard, Amandine ; Cani, Patrice D. ; Porporato, Paolo E ; Loumaye, Audrey ; Thissen, Jean-Paul ; Muccioli, Giulio ; Delzenne, Nathalie M. ; Bindels, Laure B.. Inflammation-induced cholestasis in cancer cachexia.. In: Journal of cachexia, sarcopenia and muscle, Vol. 12, no. 1, p. 70-20 (2021). doi:10.1002/jcsm.12652.
Bottemanne, Pauline ; Guillemot-Legris, Owein ; Paquot, Adrien ; Masquelier, Julien ; Malamas, Michael ; Makriyannis, Alexandros ; Al Houayek, Mireille ; Muccioli, Giulio. N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice.. In: Neurotherapeutics, , p. [1-19] (2021). doi:10.1007/s13311-021-01074-x (Accepté/Sous presse).
Suriano, Francesco ; Vieira-Silva, Sara ; Falony, Gwen ; Roumain, Martin ; Paquot, Adrien ; Pelicaen, Rudy ; Régnier, Marion ; Delzenne, Nathalie M. ; Raes, Jeroen ; Muccioli, Giulio ; Van Hul, Matthias ; Cani, Patrice D.. Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin. In: Microbiome, Vol. 9, no.1, p. 147 (2021). doi:10.1186/s40168-021-01097-8.
Neyrinck, Audrey M. ; Rodriguez, Julie (co-first author) ; Zhang, Zhengxiao ; Seethaler, Benjamin ; Robles Sanchez, Candido ; Roumain, Martin ; Hiel, Sophie ; Bindels, Laure B. ; Cani, Patrice D. ; Paquot, Nicolas ; Cnop, Miriam ; Nazare, Julie-Anne ; Laville, Martine ; Muccioli, Giulio ; Bischoff, Stephan C ; Walter, Jens ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial.. In: European journal of nutrition, Vol. 60, no. 6, p. 3159-3170 (2021). doi:10.1007/s00394-021-02484-5 (Accepté/Sous presse).
Buya, Aristote ; Terrasi, Romano ; Mbinze, Jérémie K ; Muccioli, Giulio ; Beloqui Garcia, Ana ; Memvanga, Patrick B ; Préat, Véronique. Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes.. In: Pharmaceutics, Vol. 13, no.9, p. 1388 [1-20] (2021). doi:10.3390/pharmaceutics13091388.
Lison, Dominique ; Ambroise, Jérôme ; Leinardi, Riccardo ; Ibouraadaten, Saloua ; Yakoub, Yousof ; Deumer, Gladys ; Haufroid, Vincent ; Paquot, Adrien ; Muccioli, Giulio ; Van Den Brûle, Sybille. Systemic effects and impact on the gut microbiota upon subacute oral exposure to silver acetate in rats.. In: Archives of toxicology, Vol. 95, no. 4, p. 1251-1266 (2021). doi:10.1007/s00204-021-02998-1.
Guillemot-Legris, Owein ; Muccioli, Giulio. The oxysterome and its receptors as pharmacological targets in inflammatory diseases.. In: British journal of pharmacology, (2021). doi:10.1111/bph.15479 (Accepté/Sous presse).
Pollet, Hélène ; Cloos, Anne-Sophie (co-first author) ; Stommen, Amaury ; Vanderroost, Juliette ; Conrard, Louise ; Paquot, Adrien ; Ghodsi, Marine ; Carquin, Mélanie ; Léonard, Anne-Catherine ; Guthmann, Manuel ; Lingurski, Maxime ; Vermylen, Christiane ; Killian, Theodore ; Gatto, Laurent ; Rider, Mark H. ; Pyr dit Ruys, Sébastien ; Vertommen, Didier ; Vikkula, Miikka ; Brouillard, Pascal ; Van Der Smissen, Patrick ; Muccioli, Giulio ; Tyteca, Donatienne. Aberrant Membrane Composition and Biophysical Properties Impair Erythrocyte Morphology and Functionality in Elliptocytosis. In: Biomolecules, Vol. 10, no. 8, p. 1120 [1-25] (2020). doi:10.3390/biom10081120.
Yelek, Caner ; Mignion, Lionel ; Joudiou, Nicolas ; Terrasi, Romano ; Gourgue, Florian ; Van Hul, Matthias ; Delzenne, Nathalie M. ; Gallez, Bernard ; Corbet, Cyril ; Muccioli, Giulio ; Feron, Olivier ; Cani, Patrice D. ; Jordan, Bénédicte. Acetate: Friend or foe against breast tumour growth in the context of obesity?. In: Journal of Cellular and Molecular Medicine, Vol. 24, no. 24, p. 14195-14204 (2020). doi:10.1111/jcmm.16034.
Phung, Austin S. ; Bannenberg, Gerard ; Vigor, Claire ; Reversat, Guillaume ; Oger, Camille ; Roumain, Martin ; Galano, Jean-Marie ; Durand, Thierry ; Muccioli, Giulio ; Ismail, Adam ; Wang, Selina C.. Chemical Compositional Changes in Over-Oxidized Fish Oils. In: Foods, Vol. 9, no.10, p. 1501 (2020). doi:10.3390/foods9101501.
Tsakiris, Nikolaos ; Fauvet, Frédérique ; Ruby, Samia ; Puisieux, Alain ; Paquot, Adrien ; Muccioli, Giulio ; Vigneron, Arnaud M ; Préat, Véronique. Combined nanomedicines targeting colorectal cancer stem cells and cancer cells.. In: Journal of controlled release, Vol. 326, p. 387-395 (2020). doi:10.1016/j.jconrel.2020.07.025.
Le Roy, Tiphaine ; Van Der Smissen, Patrick ; Paquot, Adrien ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Collet, Jean-François ; Cani, Patrice D.. Dysosmobacter welbionis gen. nov., sp. nov., isolated from human faeces and emended description of the genus Oscillibacter.. In: International journal of systematic and evolutionary microbiology, Vol. 70, no. 9, p. 4851-4858 (2020). doi:10.1099/ijsem.0.003547.
Al Houayek, Mireille ; Bannenberg, Gerard ; Muccioli, Giulio ; Norel, Xavier ; Yao, Chengcan ; Schebb, Nils Helge. Editorial-Special issue of the 7 European workshop on lipid mediators.. In: Prostaglandins & other lipid mediators, Vol. 148, p. 106421 [1-3] (2020). doi:10.1016/j.prostaglandins.2020.106421.
Van Hul, Matthias ; Le Roy, Tiphaine ; Prifti, Edi ; Dao, Maria Carlota ; Paquot, Adrien ; Zucker, Jean-Daniel ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Clément, Karine ; Cani, Patrice D.. From correlation to causality: the case of Subdoligranulum. In: Gut Microbes, Vol. 12, no.1, p. 1-13 (2020). doi:10.1080/19490976.2020.1849998.
Manca, Claudia ; Boubertakh, Besma ; Leblanc, Nadine ; Deschênes, Thomas ; Lacroix, Sebastien ; Martin, Cyril ; Houde, Alain ; Veilleux, Alain ; Flamand, Nicolas ; Muccioli, Giulio ; Raymond, Frédéric ; Cani, Patrice D. ; Di Marzo, Vincenzo ; Silvestri, Cristoforo. Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling.. In: Journal of lipid research, Vol. 61, no.1, p. 70-85 (2020). doi:10.1194/jlr.RA119000424.
Briand-Mésange, Fabienne ; Pons, Véronique ; Allart, Sophie ; Masquelier, Julien ; Chicanne, Gaëtan ; Beton, Nicolas ; Payrastre, Bernard ; Muccioli, Giulio ; Ausseil, Jérôme ; Davignon, Jean-Luc ; Salles, Jean-Pierre ; Chap, Hugues. Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch.. In: The Journal of biological chemistry, Vol. 295, no.46, p. 15767-15781 (2020). doi:10.1074/jbc.RA120.015278.
Lefort, Charlotte ; Roumain, Martin ; Van Hul, Matthias ; Rastelli, Marialetizia ; Manco, Rita ; Leclercq, Isabelle ; Delzenne, Nathalie M. ; Di Marzo, Vincenzo ; Flamand, Nicolas ; Luquet, Serge ; Silvestri, Cristoforo ; Muccioli, Giulio ; Cani, Patrice D.. Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism. In: Cells, Vol. 9, no. 5, p. 1247 [1-23] (2020). doi:10.3390/cells9051247.
Demaret, Tanguy ; Evraerts, Jonathan ; Ravau, Joachim ; Roumain, Martin ; Muccioli, Giulio ; Najimi, Mustapha ; Sokal, Etienne. High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in -G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment.. In: Cells, Vol. 10, no. 1, p. 40 [1-12] (2020). doi:10.3390/cells10010040.
Valderrama, Jaime A. ; Ríos, David ; Muccioli, Giulio ; Buc Calderon, Pedro ; Benites, Julio. In Vitro Inhibition of Hsp90 Protein by Benzothiazoloquinazolinequinones Is Enhanced in The Presence of Ascorbate. A Preliminary In Vivo Antiproliferative Study. In: Molecules, Vol. 25, no.4, p. 953 (2020). doi:10.3390/molecules25040953 (Accepté/Sous presse).
Cloos, Anne-Sophie ; Ghodsi, Marine ; Stommen, Amaury ; Vanderroost, Juliette ; Dauguet, Nicolas ; Pollet, Hélène ; D'Auria, Ludovic ; Mignolet, Eric ; Larondelle, Yvan ; Terrasi, Romano ; Muccioli, Giulio ; Van Der Smissen, Patrick ; Tyteca, Donatienne. Interplay Between Plasma Membrane Lipid Alteration, Oxidative Stress and Calcium-Based Mechanism for Extracellular Vesicle Biogenesis From Erythrocytes During Blood Storage.. In: Frontiers in Physiology, Vol. 11, p. 712 [1-23] (2020). doi:10.3389/fphys.2020.00712.
Rastelli, Marialetizia ; Van Hul, Matthias ; Terrasi, Romano ; Lefort, Charlotte ; Régnier, Marion ; Beiroa, Daniel ; Delzenne, Nathalie M. ; Everard, Amandine ; Nogueiras, Rubén ; Luquet, Serge ; Muccioli, Giulio ; Cani, Patrice D.. Intestinal NAPE-PLD contributes to short-term regulation of food intake via gut-to-brain axis.. In: American journal of physiology. Endocrinology and metabolism, Vol. 319, no.3, p. E647-E657 (2020). doi:10.1152/ajpendo.00146.2020.
Demaret, Tanguy ; Roumain, Martin ; Ambroise, Jérôme ; Evraerts, Jonathan ; Ravau, Joachim ; Bouzin, Caroline ; Bearzatto, Bertrand ; Gala, Jean-Luc ; Stepman, Hedwig ; Marie, Sandrine ; Vincent, Marie-Françoise ; Muccioli, Giulio ; Najimi, Mustapha ; Sokal, Etienne. Longitudinal study of Pex1-G844D NMRI mouse model: A robust pre-clinical model for mild Zellweger spectrum disorder. In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1866, no. 11, p. 165900 [1-18] (2020). doi:10.1016/j.bbadis.2020.165900.
Rodriguez, Julie ; Neyrinck, Audrey M. ; Zhang, Zhengxiao ; Seethaler, Benjamin ; Nazare, Julie-Anne ; Robles Sanchez, Candido ; Roumain, Martin ; Muccioli, Giulio ; Bindels, Laure B. ; Cani, Patrice D. ; Maquet, Véronique ; Laville, Martine ; Bischoff, Stephan C ; Walter, Jens ; Delzenne, Nathalie M.. Metabolite profiling reveals the interaction of chitin-glucan with the gut microbiota.. In: Gut microbes, Vol. 12, no. 1, p. 1810530 [1-15] (2020). doi:10.1080/19490976.2020.1810530.
Ríos, David ; Valderrama, Jaime A ; Cautin, Miriam ; Tapia, Milko ; Salas, Felipe ; Guerrero-Castilla, Angélica ; Muccioli, Giulio ; Buc Calderon, Pedro ; Benites, Julio. New 2-Acetyl-3-aminophenyl-1,4-naphthoquinones: Synthesis and Antiproliferative Activities on Breast and Prostate Human Cancer Cells.. In: Oxidative medicine and cellular longevity, Vol. 2020, p. 8939716 [1-11] (2020). doi:10.1155/2020/8939716.
Diermeier, Theresa ; Meredith, Sean J ; Irrgang, James J ; Zaffagnini, Stefano ; Kuroda, Ryosuke ; Hochino, Yuichi ; Samuelsson, Kristian ; Smith, Clair Nicole ; Popchak, Adam ; Musahl, Volker ; Sheean, Andrew ; Burnham, Jeremy M ; Lian, Jayson ; Smith, Clair ; Popchak, Adam ; Herbst, Elmar ; Pfeiffer, Thomas ; Araujo, Paulo ; Oostdyk, Alicia ; Guenther, Daniel ; Ohashi, Bruno ; Irrgang, James J ; Fu, Freddie H ; Nagamune, Kouki ; Kurosaka, Masahiro ; Kuroda, Ryosuke ; Hochino, Yuichi ; Grassi, Alberto ; Muccioli, Giulio ; Lopomo, Nicola ; Signorelli, Cecilia ; Raggi, Federico ; Zaffagnini, Stefano ; Horvath, Alexandra ; Svantesson, Eleonor ; Senorski, Eric Hamrin ; Sundemo, David ; Bjoernsson, Haukur ; Ahlden, Mattias ; Desai, Neel ; Samuelsson, Kristian ; Karlsson, Jon. Patient-Reported and Quantitative Outcomes of Anatomic Anterior Cruciate Ligament Reconstruction With Hamstring Tendon Autografts., collab. PIVOT Study Group. In: Orthopaedic journal of sports medicine, Vol. 8, no.7, p. [1-7] (2020). doi:10.1177/2325967120926159 (Accepté/Sous presse).
Orefice, Nicola S ; Guillemot-Legris, Owein ; Capasso, Rosanna ; Bottemanne, Pauline ; Hantraye, Philippe ; Caraglia, Michele ; Orefice, Giuseppe ; Al Houayek, Mireille ; Muccioli, Giulio. miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions.. In: eLife, Vol. 9, p. e56916 [1-25] (2020). doi:10.7554/eLife.56916.
Morelle, Axel ; Caruano, Joséphine ; Feledziak, Marion ; Michaux, Catherine ; Perpète, Eric ; Muccioli, Giulio ; Marchand-Brynaert, Jacqueline ; Robiette, Raphaël. β-lactams to act on the endocannabinoid system. In: Chimie Nouvelle, Vol. 134, p. 41 (2020).
Le Roy, Tiphaine ; Van Der Smissen, Patrick ; Paquot, Adrien ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Collet, Jean-François ; Cani, Patrice D.. Butyricimonas faecalis sp. nov., isolated from human faeces and emended description of the genus Butyricimonas.. In: International journal of systematic and evolutionary microbiology, Vol. 69, no.3, p. 833-838 (2019). doi:10.1099/ijsem.0.003249.
Ippolito, Luigi ; Morandi, Andrea ; Taddei, Maria Letizia ; Parri, Matteo ; Comito, Giuseppina ; Iscaro, Alessandra ; Raspollini, Maria Rosaria ; Magherini, Francesca ; Rapizzi, Elena ; Masquelier, Julien ; Muccioli, Giulio ; Sonveaux, Pierre ; Chiarugi, Paola ; Giannoni, Elisa. Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer.. In: Oncogene, Vol. 38, no. 27, p. 5339-5355 (2019). doi:10.1038/s41388-019-0805-7 (Accepté/Sous presse).
Guillemot-Legris, Owein ; Mutemberezi, Valentin ; Buisseret, Baptiste ; Paquot, Adrien ; Palmieri, Vittoria ; Bottemanne, Pauline ; Lemaire, Julien ; Rahier, Jean-François ; Al Houayek, Mireille ; Muccioli, Giulio. Colitis alters oxysterol metabolism and is affected by 4β-hydroxycholesterol administration.. In: Journal of Crohn's & colitis, Vol. 13, no. 2, p. 218-229 (2019). doi:10.1093/ecco-jcc/jjy157.
Buisseret, Baptiste ; Al Houayek, Mireille ; Guillemot-Legris, Owein ; Muccioli, Giulio. Endocannabinoid and Prostanoid Crosstalk in Pain. In: Trends in Molecular Medicine, Vol. 25, p. 882-896 (2019). doi:10.1016/j.molmed.2019.04.009.
Benites, Julio ; Valderrama, Jaime A ; Ramos, Maryan ; Valenzuela, Maudy ; Guerrero-Castilla, Angélica ; Muccioli, Giulio ; Buc Calderon, Pedro. Half-Wave Potentials and In Vitro Cytotoxic Evaluation of 3-Acylated 2,5-(phenylamino)-1,4-benzoquinones on Cancer Cells.. In: Molecules (Basel, Switzerland), Vol. 24, no.9, p. 1780 [1-14] (2019). doi:10.3390/molecules24091780.
Everard, Amandine ; Plovier, Hubert ; Rastelli, Marialetizia ; Van Hul, Matthias ; de Wouters d’Oplinter, Alice ; Geurts, Lucie ; Druart, Céline ; Robine, Sylvie ; Delzenne, Nathalie M. ; Muccioli, Giulio ; de Vos, Willem M. ; Luquet, Serge ; Flamand, Nicolas ; Di Marzo, Vincenzo ; Cani, Patrice D.. Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis. In: Nature Communications, Vol. 10, p. 457 [1-17] (2019). doi:10.1038/s41467-018-08051-7.
Buisseret, Baptiste ; Guillemot-Legris, Owein ; Muccioli, Giulio ; Al Houayek, Mireille. Prostaglandin D2-glycerol ester decreases carrageenan-induced inflammation and hyperalgesia in mice. In: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, Vol. 1864, p. 609-619 (2019).
Bottemanne, Pauline ; Paquot, Adrien ; Ameraoui, Hafsa ; Al Houayek, Mireille ; Muccioli, Giulio. The α/β–hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids. In: The FASEB Journal, Vol. 33, no. 6, p. 7635-7646 (2019). doi:10.1096/fj.201802259r.
Muccioli, Giulio ; Lizard, Gérard ; Iuliano, Luigi. Current trends in oxysterols & related sterols.. In: Biochimie : an international journal of biochemistry and molecular biology, Vol. 153, p. 1-2 (2018). doi:10.1016/j.biochi.2018.08.008.
Masquelier, Julien ; Al Houayek, Mireille ; Terrasi, Romano ; Bottemanne, Pauline ; Paquot, Adrien ; Muccioli, Giulio. Lysophosphatidylinositols in inflammation and macrophage activation: Altered levels and anti-inflammatory effects.. In: Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol. 1863, no.12, p. 1458-1468 (2018). doi:10.1016/j.bbalip.2018.09.003.
Al Houayek, Mireille ; Masquelier, Julien ; Muccioli, Giulio. Lysophosphatidylinositols, from Cell Membrane Constituents to GPR55 Ligands. In: Trends in Pharmacological Sciences, Vol. 39, no.6, p. 586-604 (2018). doi:10.1016/j.tips.2018.02.011.
Verstraeten, Sandrine ; Albert, Marie ; Paquot, Adrien ; Muccioli, Giulio ; Tyteca, Donatienne ; Mingeot-Leclercq, Marie-Paule. Membrane cholesterol delays cellular apoptosis induced by ginsenoside RH2, a steroid saponin. In: Toxicology and Applied Pharmacology, Vol. 352, p. 59–67 (2018). doi:10.1016/j.taap.2018.05.014.
Milosevic, Tamara ; Payen, Valéry ; Sonveaux, Pierre ; Muccioli, Giulio ; Tulkens, Paul M. ; Van Bambeke, Françoise. Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes.. In: Antimicrobial Agents and Chemotherapy, Vol. 62, no. 3, p. e01599-17 [1-17] (2018). doi:10.1128/AAC.01599-17.
Bottemanne, Pauline ; Muccioli, Giulio ; Al Houayek, Mireille. N -acylethanolamine hydrolyzing acid amidase inhibition: tools and potential therapeutic opportunities. In: Drug Discovery Today, Vol. 23, no. 8, p. 1520-1529 (2018). doi:10.1016/j.drudis.2018.03.007.
Mutemberezi, Valentin ; Buisseret, Baptiste ; Masquelier, Julien ; Guillemot-Legris, Owein ; Al Houayek, Mireille ; Muccioli, Giulio. Oxysterol levels and metabolism in the course of neuroinflammation: insights from in vitro and in vivo models. In: Journal of Neuroinflammation, Vol. 15, no.1, p. 1-10 (2018). doi:10.1186/s12974-018-1114-8.
Guillemot-Legris, Owein ; Buisseret, Baptiste ; Mutemberezi, Valentin ; Hermans, Emmanuel ; Deumens, Ronald ; Al Houayek, Mireille ; Muccioli, Giulio. Post-operative pain in mice is prolonged by diet-induced obesity and rescued by dietary intervention.. In: Brain, Behavior, and Immunity, (2018). doi:10.1016/j.bbi.2018.07.022.
Xu, Yining ; Carradori, Dario ; Al Houayek, Mireille ; Muccioli, Giulio ; Cani, Patrice D. ; Préat, Véronique ; Beloqui Garcia, Ana. Size Effect on Lipid Nanocapsule-Mediated GLP-1 Secretion from Enteroendocrine L Cells.. In: Molecular pharmaceutics, Vol. 15, no. 1, p. 108-115 (2018). doi:10.1021/acs.molpharmaceut.7b00742.
De Berdt, Pauline ; Bottemanne, Pauline ; Bianco, John ; Al Houayek, Mireille ; Diogenes, Anibal ; Llyod, Amy ; Gerardo-Nava, Jose ; Brook, Gary A. ; Miron, Véronique ; Muccioli, Giulio ; des Rieux, Anne. Stem cells from human apical papilla decrease neuro-inflammation and stimulate oligodendrocyte progenitor differentiation via activin-A secretion. In: Cellular and Molecular Life Sciences, Vol. 75, p. 2843-2856 (2018). doi:10.1007/s00018-018-2764-5.
Benites, Julio ; Valderrama, Jaime A ; Ramos, Maryan ; Muccioli, Giulio ; Buc Calderon, Pedro. Targeting Akt as strategy to kill cancer cells using 3-substituted 5-anilinobenzo[c]isoxazolequinones: A preliminary study.. In: Biomedicine & Pharmacotherapy, Vol. 97, p. 778-783 (2017). doi:10.1016/j.biopha.2017.10.108.
Al Houayek, Mireille ; Buisseret, Baptiste ; Paquot, Adrien ; Guillemot-Legris, Owein ; Muccioli, Giulio. The endogenous bioactive lipid prostaglandin D2-glycerol ester reduces murine colitis via DP1 and PPARγ receptors. In: The FASEB Journal, , p. fj.201701205R (2018). doi:10.1096/fj.201701205r (Accepté/Sous presse).
Beaumont, Martin ; Neyrinck, Audrey M. ; Olivares Sevilla, Marta ; Rodriguez, Julie ; de Rocca Serra, Audrey ; Roumain, Martin ; Bindels, Laure B. ; Cani, Patrice D. ; Evenepoel, Pieter ; Muccioli, Giulio ; Demoulin, Jean-Baptiste ; Delzenne, Nathalie M.. The gut microbiota metabolite indole alleviates liver inflammation in mice.. In: The FASEB Journal, Vol. 32, no. 12, p. fj201800544 [1-13] (2018). doi:10.1096/fj.201800544.
Carradori, Dario ; Dos Santos, Andreia ; Masquelier, Julien ; Paquot, Adrien ; Saulnier, Patrick ; Eyer, Joël ; Préat, Véronique ; Muccioli, Giulio ; Mingeot-Leclercq, Marie-Paule ; des Rieux, Anne. The origin of neural stem cells impacts their interactions with targeted-lipid nanocapsules: Potential role of plasma membrane lipid composition and fluidity. In: Journal of Controlled Release, Vol. 292, p. 248-255 (2018). doi:10.1016/j.jconrel.2018.11.005.
Newson, Justine ; Motwani, Madhur P. ; Kendall, Alexandra C. ; Nicolaou, Anna ; Muccioli, Giulio ; Al Houayek, Mireille ; Bennett, Melanie ; Van De Merwe, Rachel ; James, Sarah ; De Maeyer, Roel P.H. ; Gilroy, Derek W.. Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E 2. In: Cell Reports, Vol. 20, no. 13, p. 3162-3175 (2017). doi:10.1016/j.celrep.2017.08.098.
Al Houayek, Mireille ; Bottemanne, Pauline ; Makriyannis, Alexandros ; Muccioli, Giulio. N-acylethanolamine-hydrolyzing acid amidase and fatty acid amide hydrolase inhibition differentially affect N-acylethanolamine levels and macrophage activation. In: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, Vol. 1862, no. 5, p. 474-484 (2017). doi:10.1016/j.bbalip.2017.01.001.
Guillemot, Owein ; Muccioli, Giulio. Obesity-Induced Neuroinflammation: Beyond the Hypothalamus. In: Trends in Neurosciences, Vol. 40, no.4, p. 237-253 (2017). doi:10.1016/j.tins.2017.02.005.
Buyck, Julien ; Luyckx, C. ; Muccioli, Giulio ; Krause, K.M. ; Nichols, W. W. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamics of ceftazidime/avibactam against extracellular and intracellular forms of Pseudomonas aeruginosa. In: Journal of Antimicrobial Chemotherapy, Vol. 72, no.5, p. 1400-1409 (2017). doi:10.1093/jac/dkw587.
Van Hee, Vincent F ; Labar, Daniel ; Dehon, Gwenaël ; Grasso, Debora ; Gregoire, Vincent ; Muccioli, Giulio ; Frédérick, Raphaël ; Sonveaux, Pierre. Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. In: OncoTarget, Vol. 8, no. 15, p. 24415-24428 (2017). doi:10.18632/oncotarget.14705.
Bindels, Laure B. ; Segura Munoz, Rafael R ; Gomes-Neto, João Carlos ; Mutemberezi, Valentin ; Martínez, Inés ; Salazar, Nuria ; Cody, Elizabeth A ; Quintero-Villegas, Maria I ; Kittana, Hatem ; de Los Reyes-Gavilán, Clara G ; Schmaltz, Robert J ; Muccioli, Giulio ; Walter, Jens ; Ramer-Tait, Amanda E. Resistant starch can improve insulin sensitivity independently of the gut microbiota. In: Microbiome, Vol. 5, no.1, p. 12 [1-16] (2017). doi:10.1186/s40168-017-0230-5.
Valderrama, Jaime A. ; Cabrera, Mónica ; Benites, Julio ; Ríos, David ; Inostroza-Rivera, Ricardo ; Muccioli, Giulio ; Buc Calderon, Pedro. Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones. In: R S C Advances : an international journal to further the chemical sciences, Vol. 7, no.40, p. 24813-24821 (2017). doi:10.1039/c7ra03238b.
Beloqui Garcia, Ana ; Al Houayek, Mireille ; Carradori, Dario ; Vanvarenberg, Kevin ; Muccioli, Giulio ; Cani, Patrice D. ; Préat, Véronique. A Mechanistic Study on Nanoparticle-Mediated Glucagon-Like Peptide-1 (GLP-1) Secretion from Enteroendocrine L Cells.. In: Molecular Pharmaceutics, Vol. 13, no.12, p. 4222-4230 (2016). doi:10.1021/acs.molpharmaceut.6b00871.
Beloqui Garcia, Ana ; Memvanga Bondo, Patrick ; Coco, Régis ; Reimondez-Troitiño, Sonia ; Al Houayek, Mireille ; Muccioli, Giulio ; Alonso, María José ; Csaba, Noemi ; de la Fuente, María ; Préat, Véronique. A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease.. In: Colloids and Surfaces B: Biointerfaces, Vol. 143, p. 327-335 (2016). doi:10.1016/j.colsurfb.2016.03.038.
Ibacache, Juana Andrea ; Valderrama, Jaime A ; Arancibia, Verónica ; Theoduloz, Cristina ; Muccioli, Giulio ; Benites, Julio. Antiproliferative activity of new 6-bromine derivatives of 7-anilino-1-arylisoquinolinequinones. In: Journal of the Chilean Chemical Sociaty, Vol. 61, no. 4, p. 3191-3194 (2016). doi:10.4067/S0717-97072016000400008.
Caruano, Joséphine ; Muccioli, Giulio ; Robiette, Raphaël. Biologically active γ-lactams: synthesis and natural sources. In: Organic & Biomolecular Chemistry, Vol. 14, no.43, p. 10134-10156 (2016). doi:10.1039/C6OB01349J.
Guada ramirez, Melissa ; Beloqui Garcia, Ana ; Al Houayek, Mireille ; Muccioli, Giulio ; Dios-Viéitez, Maria del Carmen ; Préat, Véronique ; Blanco-Prieto, Maria J.. Cyclosporine A-loaded lipid nanoparticles in inflammatory bowel disease. In: International Journal of Pharmaceutics, Vol. 503, no. 1-2, p. 196-198 (2016). doi:10.1016/j.ijpharm.2016.03.012.
Masquelier, Julien ; Muccioli, Giulio. Development and validation of a specific and sensitive HPLC-ESI-MS method for quantification of lysophosphatidylinositols and evaluation of their levels in mice tissues. In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 126, no.1, p. 132-140 (2016). doi:10.1016/j.jpba.2016.04.011.
Mutemberezi, Valentin ; Masquelier, Julien ; Guillemot-Legris, Owein ; Muccioli, Giulio. Development and validation of an HPLC-MS method for the simultaneous quantification of key oxysterols, endocannabinoids, and ceramides: variations in metabolic syndrome. In: Analytical and Bioanalytical Chemistry, Vol. 408, no. 3, p. 733-745 (2016). doi:10.1007/s00216-015-9150-z.
Guillemot-Legris, Owein ; Masquelier, Julien ; Everard, Amandine ; Cani, Patrice D. ; Al Houayek, Mireille ; Muccioli, Giulio. High-fat diet feeding differentially affects the development of inflammation in the central nervous system. In: Journal of Neuroinflammation, Vol. 13, no.1, p. 206 [1-11] (2016). doi:10.1186/s12974-016-0666-8.
Gerin, Isabelle ; Ury, Benoît ; Breloy, Isabelle ; Bouchet-Seraphin, Céline ; Bolsée, Jennifer ; Halbout, Mathias ; Graff, Julie ; Vertommen, Didier ; Muccioli, Giulio ; Seta, Nathalie ; Cuisset, Jean-Marie ; Dabaj, Ivana ; Quijano-Roy, Susana ; Grahn, Ammi ; Van Schaftingen, Emile ; Bommer, Guido. ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan. In: Nature Communications, Vol. 7, no. 1, p. 11534 [1-15] (2016). doi:10.1038/ncomms11534.
Mignion, Lionel ; Danhier, Pierre ; Magat, Julie ; Porporato, Paolo ; Masquelier, Julien ; Grégoire, Vincent ; Muccioli, Giulio ; Sonveaux, Pierre ; Gallez, Bernard ; Jordan, Bénédicte. Non-invasive in vivo imaging of early metabolic tumor response to therapies targeting choline metabolism.. In: International Journal of Cancer, Vol. 138, no. 8, p. 2043-2049 (2016). doi:10.1002/ijc.29932.
Guillemot-Legris, Owein ; Mutemberezi, Valentin ; Cani, Patrice D. ; Muccioli, Giulio. Obesity is associated with changes in oxysterol metabolism and levels in mice liver, hypothalamus, adipose tissue and plasma.. In: Scientific Reports, Vol. 6, p. 19694 [1-11] (2016). doi:10.1038/srep19694.
Orefice, Nicola S. ; Al Houayek, Mireille ; Carotenuto, Antonio ; Montella, Silvana ; Barbato, Franscesco ; Comelli, Albert ; Calignano, Antonio ; Muccioli, Giulio ; Orefice, Giuseppe. Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines in Relapsing–Remitting Multiple Sclerosis. In: Neurotherapeutics, Vol. 13, no. 2, p. 428-438 (2016). doi:10.1007/s13311-016-0420-z.
Guillemot-Legris, Owein ; Mutemberezi, Valentin ; Muccioli, Giulio. Oxysterols in Metabolic Syndrome: From Bystander Molecules to Bioactive Lipids. In: Trends in Molecular Medicine, Vol. 22, no. 7, p. 594-614 (2016). doi:10.1016/j.molmed.2016.05.006.
Mutemberezi, Valentin ; Guillemot-Legris, Owein ; Muccioli, Giulio. Oxysterols: From cholesterol metabolites to key mediators. In: Progress in Lipid Research, Vol. 64, p. 152-169 (2016). doi:10.1016/j.plipres.2016.09.002.
Luo, Tian ; Loira Pastoriza, Cristina ; Patil, Harshad Padmanabh ; Ucakar, Bernard ; Muccioli, Giulio ; Bosquillon, Cynthia ; Vanbever, Rita. PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma.. In: Journal of Controlled Release, Vol. 239, p. 62-71 (2016). doi:10.1016/j.jconrel.2016.08.008.
Lepannetier, Sophie ; Zanou, Bidossessi Nadège ; Yerna, Xavier ; Emeriau, Noémie ; Dufour, Inès ; Masquelier, Julien ; Muccioli, Giulio ; Tajeddine, Nicolas ; Gailly, Philippe. Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells.. In: Cell Calcium, Vol. 60, no. 6, p. 373-383 (2016). doi:10.1016/j.ceca.2016.09.002.
Valderrama, Jaime ; Delgado, Virginia ; Sepúlveda, Sandra ; Benites, Julio ; Theoduloz, Cristina ; Buc Calderon, Pedro ; Muccioli, Giulio. Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone–Amino Acid Derivatives. In: Molecules : a journal of synthetic organic and natural product chemistry, Vol. 21, no. 9, p. 1199 [1-14] (2016). doi:10.3390/molecules21091199.
Geurts, Lucie ; Everard, Amandine ; Van Hul, Matthias ; Essaghir, Ahmed ; Duparc, Thibaut ; Matamoros, Sébastien ; Plovier, Hubert ; Castel, Julien ; Denis, Raphael G P ; Bergiers, Marie ; Druart, Céline ; Al Houayek, Mireille ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Demoulin, Jean-Baptiste ; Luquet, Serge ; Cani, Patrice D.. Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. In: Nature Communications, Vol. 6, p. 6495 [1-15] (2015). doi:10.1038/ncomms7495.
El Bakali, Jamal ; Muccioli, Giulio ; Body-Malapel, Mathilde ; Djouina, Madjid ; Klupsch, Frédérique ; Ghinet, Alina ; Barczyk, Amélie ; Renault, Nicolas ; Chavatte, Philippe ; Desreumaux, Pierre ; Lambert, Didier ; Millet, Régis. Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis. In: ACS Medicinal Chemistry Letters, Vol. 6, no.2, p. 198-203 (2015). doi:10.1021/ml500439x.
Izzo, Angelo A ; Muccioli, Giulio ; Ruggieri, Michael R ; Schicho, Rudolf. Endocannabinoids and the Digestive Tract and Bladder in Health and Disease.. In: Handbook of Experimental Pharmacology, Vol. 231, p. 423-447 (2015). doi:10.1007/978-3-319-20825-1_15.
Valderrama, Jaime A. ; Ríos, David ; Muccioli, Giulio ; Buc Calderon, Pedro ; Brito, Iván ; Benites, Julio. Hetero-annulation reaction between 2-acylnaphthoquinones and 2-aminobenzothiazoles. A new synthetic route to antiproliferative benzo[g]benzothiazolo[2,3-b]quinazoline-7,12-quinones. In: Tetrahedron Letters, Vol. 56, no.36, p. 5103-5105 (2015). doi:10.1016/j.tetlet.2015.07.034.
Bosier, Barbara ; Doyen, Pierre ; Brolet, Amandine ; Muccioli, Giulio ; Ahmed, Eman ; Desmet, Nathalie ; Hermans, Emmanuel ; Deumens, Ronald. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.. In: British Journal of Pharmacology, Vol. 172, no.22, p. 5333-5346 (2015). doi:10.1111/bph.13324.
Vandevelde, Nathalie ; Tulkens, Paul M. ; Muccioli, Giulio ; Van Bambeke, Françoise. Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms. In: Journal of Antimicrobial Chemotherapy, Vol. 70, no. 6, p. 1713-1726 (2015). doi:10.1093/jac/dkv032.
Al Houayek, Mireille ; Bottemanne, Pauline ; Subramanian, Kumar V ; Lambert, Didier ; Makriyannis, Alexandros ; Cani, Patrice D. ; Muccioli, Giulio. N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis. In: The FASEB Journal, Vol. 29, no.2, p. 650-661 (2015). doi:10.1096/fj.14-255208.
Bindels, Laure B. ; Neyrinck, Audrey M. (co-first author) ; Salazar Garzo, Nuria ; Taminiau, Bernard ; Druart, Céline ; Muccioli, Giulio ; François, Emmanuelle ; Blecker, Christophe ; Richel, Aurore ; Daube, Georges ; Mahillon, Jacques ; de Los Reyes-Gavilán, Clara G ; Cani, Patrice D. ; Delzenne, Nathalie M.. Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice. In: PLoS One, Vol. 10, no. 6, p. e0131009 [1-16] (2015). doi:10.1371/journal.pone.0131009.
Caruano, Joséphine ; Feledziak, Marion ; Labar, Geoffray ; Michaux, Catherine ; Perpete, Eric ; Muccioli, Giulio ; Robiette, Raphaël ; Marchand-Brynaert, Jacqueline. (S)-1-(Pent-4’-enoyl)-4-(hydroxymethyl)-azetidin-2-one derivatives as inhibitors of human fatty acid amide hydrolase (hFAAH): synthesis, biological evaluation and molecular modelling. In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 29, no. /, p. 654-662 (2014). doi:10.3109/14756366.2013.837900.
Al Houayek, Mireille ; Muccioli, Giulio. COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. In: Trends in Pharmacological Sciences, Vol. 35, no.6, p. 284-292 (2014). doi:10.1016/j.tips.2014.03.001.
Al Houayek, Mireille ; Masquelier, Julien ; Muccioli, Giulio. Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. In: Drug Discovery Today, Vol. 19, no. 3, p. 295-304 (2014). doi:10.1016/j.drudis.2013.07.009.
Reychler, Gregory ; Aubriot, Anne-Sophie ; Masquelier, Julien ; Muccioli, Giulio ; Liistro, Giuseppe. Effect of drug-targeting nebulization on lung delivery. In: Archivos de Bronconeumologia, Vol. 50, no. 3, p. 500-501 (2014). doi:10.1016/j.arbres.2013.10.014.
Al Houayek, Mireille ; Muccioli, Giulio. Harnessing the anti-inflammatory potential of palmitoylethanolamide.. In: Drug discovery today, , no.1-8 (2014). doi:10.1016/j.drudis.2014.06.007 (Accepté/Sous presse).
Everard, Amandine ; Geurts, Lucie ; Caesar, Robert ; Van Hul, Matthias ; Matamoros, Sébastien ; Duparc, Thibaut ; Denis, Raphael G P ; Cochez, Perrine ; Pierard, Florian ; Castel, Julien ; Bindels, Laure B. ; Plovier, Hubert ; Robine, Sylvie ; Muccioli, Giulio ; Renauld, Jean-Christophe ; Dumoutier, Laure ; Delzenne, Nathalie M. ; Luquet, Serge ; Bäckhed, Fredrik ; Cani, Patrice D.. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. In: Nature Communications, Vol. 5, no. 1, p. 5648 [1-12] (2014). doi:10.1038/ncomms6648.
Ibacache, Juana Andrea ; Delgado, Virginia ; Benites, Julio ; Theoduloz, Cristina ; Arancibia, Verónica ; Muccioli, Giulio ; Valderrama, Jaime A. Synthesis, half-wave potentials and antiproliferative activity of 1-aryl-substituted aminoisoquinolinequinones.. In: Molecules (Basel, Switzerland), Vol. 19, no.1, p. 726-39 (2014). doi:10.3390/molecules19010726.
Tourteau, Aurélien ; Andrzejak, Virginie ; Body-Malapel, Mathilde ; Lemaire, Lucas ; Lemoine, Amélie ; Mansouri, Roxane ; Djouina, Madjid ; Renault, Nicolas ; El Bakali, Jamal ; Desreumaux, Pierre ; Muccioli, Giulio ; Lambert, Didier M ; Chavatte, Philippe ; Rigo, Benoît ; Leleu-Chavain, Natascha ; Millet, Régis. 3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.. In: Bioorganic & medicinal chemistry, Vol. 21, no. 17, p. 5383-94 (2013). doi:10.1016/j.bmc.2013.06.010.
Beloqui Garcia, Ana ; Coco, Régis ; Al Houayek, Mireille ; Solinís, María Ángeles ; Rodríguez-Gascón, Alicia ; Muccioli, Giulio ; Préat, Véronique. Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis. In: International Journal of Pharmaceutics, Vol. 454, no. 2, p. 775-783 (2013). doi:10.1016/j.ijpharm.2013.05.017.
Geurts, Lucie ; Muccioli, Giulio ; Delzenne, Nathalie M. ; Cani, Patrice D.. Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia. In: PLoS One, Vol. 8, no.2, p. e55963 [1-10] (2013). doi:10.1371/journal.pone.0055963.
Everard, Amandine ; Belzer, Clara ; Geurts, Lucie ; Ouwerkerk, Janneke P ; Druart, Céline ; Bindels, Laure B. ; Guiot, Yves ; Derrien, Muriel ; Muccioli, Giulio ; Delzenne, Nathalie M. ; de Vos, Willem M ; Cani, Patrice D.. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. In: Proceedings of the National academy of sciences of the United States of America, Vol. 110, no.22, p. 9066-9071 (2013). doi:10.1073/pnas.1219451110.
Arenas, Paola ; Peña, Andrés ; Ríos, David ; Benites, Julio ; Muccioli, Giulio ; Buc Calderon, Pedro ; Valderrama, Jaime A. Eco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones. In: Molecules, Vol. 18, no. 8, p. 9818-9832 (2013). doi:10.3390/molecules18089818.
Al Houayek, Mireille ; Masquelier, Julien ; Cani, Patrice D. ; Lambert, Didier M. ; Muccioli, Giulio. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. In: Proceedings of the National academy of sciences of the United States of America, Vol. 110, no.43, p. 17558-17563 (2013). doi:10.1073/pnas.1314017110.
Bosier, Barbara ; Muccioli, Giulio ; Lambert, Didier. The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB(1) and FAAH-independent mechanisms. In: British Journal of Pharmacology, Vol. 169, no. 4, p. 794-807 (2013). doi:10.1111/j.1476-5381.2012.02208.x.
El Bakali, Jamal ; Gilleron, Pauline ; Body-Malapel, Mathilde ; Mansouri, Roxane ; Muccioli, Giulio ; Djouina, Madjid ; Barczyk, Amélie ; Klupsch, Frédérique ; Andrzejak, Virginie ; Lipka, Emmanuelle ; Furman, Christophe ; Lambert, Didier ; Chavatte, Philippe ; Desreumaux, Pierre ; Millet, Régis. 4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis. In: Journal of Medicinal Chemistry, Vol. 55, no. 20, p. 8948-8952 (2012). doi:10.1021/jm3008568.
Bosier, Barbara ; Muccioli, Giulio ; Mertens, Birgit ; Sarre, Sophie ; Michotte, Yvette ; Lambert, Didier M ; Hermans, Emmanuel. Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.. In: Neuropharmacology, Vol. 62, no. 7, p. 2328-2336 (2012). doi:10.1016/j.neuropharm.2012.02.003.
Matuszak, Nicolas ; Hamtiaux, Laurie ; Baldeyroux, Brigitte ; Muccioli, Giulio ; Poupaert, Jacques H ; Lansiaux, Amélie ; Lambert, Didier M. Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth.. In: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Vol. 45, no. 3, p. 263-71 (2012). doi:10.1016/j.ejps.2011.11.011.
Bindels, Laure B. ; Porporato, Paolo ; Dewulf, Evelyne ; Verrax, Julien ; Neyrinck, Audrey M. ; Martin, J C ; Scott, K P ; Buc Calderon, Pedro ; Feron, Olivier ; Muccioli, Giulio ; Sonveaux, Pierre ; Cani, Patrice D. ; Delzenne, Nathalie M.. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. In: The British journal of cancer, Vol. 107, no. 8, p. 1337-1344 (2012). doi:10.1038/bjc.2012.409.
Feledziak, Marion ; Lambert, Didier, M. ; Marchand-Brynaert, Jacqueline ; Muccioli, Giulio. Inhibitors of the Endocannabinoid-Degrading Enzymes, or how to Increase Endocannabinoid's Activity by Preventing their Hydrolysis. In: Recent Patents on C N S Drug Discovery, Vol. 7, no.1, p. 49-70 (2012). doi:10.2174/157488912798842223.
Kapanda, Coco N ; Masquelier, Julien ; Labar, Geoffray ; Muccioli, Giulio ; Poupaert, Jacques H ; Lambert, Didier M. Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors.. In: Journal of medicinal chemistry, Vol. 55, no. 12, p. 5774-83 (2012). doi:10.1021/jm3006004.
Hamtiaux, Laurie ; Masquelier, Julien ; Muccioli, Giulio ; Bouzin, Caroline ; Feron, Olivier ; Gallez, Bernard ; Lambert, Didier. The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action. In: BMC Cancer, Vol. 12, p. 92 [1-12] (2012). doi:10.1186/1471-2407-12-92.
Al Houayek, Mireille ; Muccioli, Giulio. The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. In: Trends in Molecular Medicine, Vol. 18, no. 10, p. 615-625 (2012). doi:10.1016/j.molmed.2012.07.009.
Geurts, Lucie ; Lazarevic, Vladimir ; Derrien, Muriel ; Everard, Amandine ; Van Roye, Marie ; Knauf, Claude ; Valet, Philippe ; Girard, Myriam ; Muccioli, Giulio ; François, Patrice ; de Vos, Willem M. ; Schrenzel, Jacques ; Delzenne, Nathalie M. ; Cani, Patrice D.. Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice : impact on apelin regulation in adipose tissue.. In: Frontiers in Microbiology, Vol. 2, p. [1-17] (2011). doi:10.3389/fmicb.2011.00149.
Marrs, William R. ; Horne, Eric A. ; Ortega-Gutierrez, Silvia ; Cisneros, Jose Antonio ; Xu, Cong ; Lin, Yi Hsing ; Muccioli, Giulio ; Lopez-Rodriguez, Maria L. ; Stella, Nephi. Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. In: Journal of Biological Chemistry, Vol. 286, no. 33, p. 28723-8 (2011). doi:10.1074/jbc.M110.202853.
Pachikian, Barbara D. ; Essaghir, Ahmed ; Demoulin, Jean-Baptiste ; Neyrinck, Audrey M. ; Catry, Emilie ; De Backer, Fabienne ; Dejeans, Nicolas ; Dewulf, Evelyne ; Sohet, Florence ; Portois, Laurence ; Deldicque, Louise ; Molendi-Coste, Olivier ; Leclercq, Isabelle ; Francaux, Marc ; Carpentier, Yvon A ; Foufelle, Fabienne ; Muccioli, Giulio ; Cani, Patrice D. ; Delzenne, Nathalie M.. Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice : genomic analysis of cellular targets.. In: PLoS One, Vol. 6, no. 8, p. e23365 (2011). doi:10.1371/journal.pone.0023365.
Hamtiaux, Laurie ; Hansoulle, Laurie ; Dauguet, Nicolas ; Muccioli, Giulio ; Gallez, Bernard ; Lambert, Didier. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. In: PLoS One, Vol. 6, no. 10, p. [1-14] (2011). doi:10.1371/journal.pone.0026823.
Al Houayek, Mireille ; Lambert, Didier ; Delzenne, Nathalie M. ; Cani, Patrice D. ; Muccioli, Giulio. Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. In: The FASEB Journal, Vol. 25, no. 8, p. 2711-2721 (2011). doi:10.1096/fj.10-176602.
Dewulf, Evelyne ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Possemiers, Sam ; Van Holle, Ann ; Muccioli, Giulio ; Deldicque, Louise ; Bindels, Laure B. ; Pachikian, Barbara D. ; Sohet, Florence ; Mignolet, Eric ; Francaux, Marc ; Larondelle, Yvan ; Delzenne, Nathalie M.. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice.. In: The Journal of Nutritional Biochemistry, Vol. 22, no. 8, p. 712-722 (2011). doi:10.1016/j.jnutbio.2010.05.009.
Duparc, Thibaut ; Naslain, Damien ; Colom, André ; Muccioli, Giulio ; Massaly, Nicolas ; Delzenne, Nathalie M. ; Valet, Philippe ; Cani, Patrice D. ; Knauf, Claude. Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus.. In: Antioxidants & Redox Signaling, Vol. 14, no. 3, p. 415-423 (2011). doi:10.1089/ars.2010.3330.
Thabuis, Clémentine ; Destaillats, Frédéric ; Lambert, Didier ; Muccioli, Giulio ; Maillot, Matthieu ; Harach, Touafiq ; Tissot-Favre, Delphine ; Martin, Jean-Charles. Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice. In: Journal of Lipid Research, Vol. 52, no. 7, p. 1373-82 (2011). doi:10.1194/jlr.M013391.
Sexton, Michelle ; Woodruff, Grace ; Horne, Eric A. ; Lin, Yi Hsing ; Muccioli, Giulio ; Bai, Mingfeng ; Stern, Eric ; Bornhop, Darryl J. ; Stella, Nephi. NIR-mbc94, a fluorescent ligand that binds to endogenous CB(2) receptors and is amenable to high-throughput screening. In: Chemistry & Biology, Vol. 18, no. 5, p. 563-568 (2011). doi:10.1016/j.chembiol.2011.02.016.
Andrzejak, Virginie ; Muccioli, Giulio ; Body-Malapel, Mathilde ; El Bakali, Jamal ; Djouina, Madjid ; Renault, Nicolas ; Chavatte, Philippe ; Desreumaux, Pierre ; Lambert, Didier ; Millet, Régis. New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis. In: Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 19, no. 12, p. 3777-3786 (2011). doi:10.1016/j.bmc.2011.04.057.
Everard, Amandine ; Lazarevic, Vladimir ; Derrien, Muriel ; Girard, Myriam ; Muccioli, Giulio ; Neyrinck, Audrey M. ; Possemiers, Sam ; Van Holle, Ann ; François, Patrice ; de Vos, Willem M ; Delzenne, Nathalie M. ; Schrenzel, Jacques ; Cani, Patrice D.. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. In: Diabetes, Vol. 60, no. 11, p. 2775-2786 (2011). doi:10.2337/db11-0227.
Feledziak, Marion ; Muccioli, Giulio ; Lambert, Didier ; Marchand-Brynaert, Jacqueline. SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH) : evidence of a nonhydrolytic process. In: Journal of Medicinal Chemistry, Vol. 54, no. 19, p. 6812-6823 (2011). doi:10.1021/jm200723m.
Evens, Nele ; Vandeputte, Caroline ; Muccioli, Giulio ; Lambert, Didier ; Baekelandt, Veerle ; Verbruggen, Alfons M. ; Debyser, Zeger ; Van Laere, Koen ; Bormans, Guy M.. Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging. In: Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 19, no. 15, p. 4499-4505 (2011). doi:10.1016/j.bmc.2011.06.033.
El Bakali, Jamal ; Muccioli, Giulio ; Renault, Nicolas ; Pradal, Delphine ; Body-Malapel, Mathilde ; Djouina, Madjid ; Hamtiaux, Laurie ; Andrzejak, Virginie ; Desreumaux, Pierre ; Chavatte, Philippe ; Lambert, Didier ; Millet, Régis. 4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands : structural insights into the design of a novel inverse agonist series.. In: Journal of Medicinal Chemistry, Vol. 53, no. 22, p. 7918-7931 (2010). doi:10.1021/jm100286k.
De Wael, Frédéric ; Muccioli, Giulio ; Lambert, Didier ; Sergent, Thérèse ; Schneider, Yves-Jacques ; Rees, Jean-François ; Marchand-Brynaert, Jacqueline. Chemistry around imidazopyrazine and ibuprofen : discovery of novel fatty acid amide hydrolase (FAAH) inhibitors. In: European Journal of Medicinal Chemistry, Vol. 45, no. 9, p. 3564-3574 (2010). doi:10.1016/j.ejmech.2010.04.040.
Muccioli, Giulio. Endocannabinoid biosynthesis and inactivation, from simple to complex.. In: Drug Discovery Today, Vol. 15, no. 11-12, p. 474-483 (2010). doi:10.1016/j.drudis.2010.03.007.
Bosier, Barbara ; Muccioli, Giulio ; Hermans, Emmanuel ; Lambert, Didier. Functionally selective cannabinoid receptor signalling : therapeutic implications and opportunities. In: Biochemical Pharmacology, Vol. 80, no. 1, p. 1-12 (2010). doi:10.1016/j.bcp.2010.02.013.
Collard, François ; Stroobant, Vincent ; Lamosa, Pedro ; Kapanda Nankwa, Coco ; Lambert, Didier ; Muccioli, Giulio ; Poupaert, Jacques ; Opperdoes, Frederik ; Van Schaftingen, Emile. Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.. In: Journal of Biological Chemistry, Vol. 285, no. 39, p. 29826-29833 (2010). doi:10.1074/jbc.M110.152629.
Wyffels, Leonie ; Muccioli, Giulio ; Kapanda Nankwa, Coco ; Labar, Geoffray ; De Bruyne, Sylvie ; De Vos, Filip ; Lambert, Didier. PET imaging of fatty acid amide hydrolase in the brain : synthesis and biological evaluation of an C-11-labelled URB597 analogue. In: Nuclear Medicine and Biology, Vol. 37, no. 5, p. 665-75 (2010). doi:10.1016/j.nucmedbio.2010.03.009.
Muccioli, Giulio ; Naslain, Damien ; Bäckhed, Fredrik ; Reigstad, Christopher S. ; Lambert, Didier ; Delzenne, Nathalie M. ; Cani, Patrice D.. The endocannabinoid system links gut microbiota to adipogenesis. In: Molecular Systems Biology, Vol. 6, p. 392 [1-15] (2010). doi:10.1038/msb.2010.46.
Marrs, William R. ; Blankman, Jacqueline L. ; Horne, Eric A. ; Thomazeau, Aurore ; Lin, Yi Hsing ; Coy, Jonathan ; Bodor, Agnes L. ; Muccioli, Giulio ; Hu, Sherry Shu-Jung ; Woodruff, Grace ; Fung, Susan ; Lafourcade, Mathieu ; Alexander, Jessica P. ; Long, Jonathan Z. ; Li, Weiwei ; Xu, Cong ; Moeller, Thomas ; Mackie, Ken ; Manzoni, Olivier J. ; Cravatt, Benjamin F. ; Stella, Nephi. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. In: Nature Neuroscience, Vol. 13, no. 8, p. 951-7 (2010). doi:10.1038/nn.2601.
Feledziak, Marion ; Michaux, Catherine ; Urbach, Allan ; Labar, Geoffray ; Muccioli, Giulio ; Lambert, Didier ; Marchand-Brynaert, Jacqueline. Beta-lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase. In: Journal of Medicinal Chemistry, Vol. 52, no. 22, p. 7054-7068 (2009). doi:10.1021/jm9008532.
Kapanda, Coco N. ; Muccioli, Giulio ; Labar, Geoffray ; Poupaert, Jacques ; Lambert, Didier. Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors. In: Journal of Medicinal Chemistry, Vol. 52, no. 22, p. 7310-7314 (2009). doi:10.1021/jm901323s.
Cani, Patrice D. ; Possemiers, S. ; Van de Wiele, T. ; Guiot, Yves ; Everard, Amandine ; Rottier, O. ; Geurts, Lucie ; Naslain, Damien ; Neyrinck, Audrey M. ; Lambert, Didier ; Muccioli, Giulio ; Delzenne, Nathalie M.. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. In: Gut, Vol. 58, no. 8, p. 1091-1103 (2009). doi:10.1136/gut.2008.165886.
Muccioli, Giulio ; Sia, Angela ; Muchowski, Paul J. ; Stella, Nephi. Genetic manipulation of palmitoylethanolamide production and inactivation in Saccharomyces cerevisiae.. In: PLoS One, Vol. 4, no. 6, p. e5942 (2009). doi:10.1371/journal.pone.0005942.
Kapanda Nankwa, Coco ; Muccioli, Giulio ; Labar, Geoffray ; Draoui, Nihed ; Lambert, Didier ; Poupaert, Jacques. Search for monoglyceride lipase inhibitors : synthesis and screening of arylthioamides derivatives. In: Medicinal Chemistry Research, Vol. 18, no. 4, p. 243-254 (2009). doi:10.1007/s00044-008-9123-2.
Evens, Nele ; Muccioli, Giulio ; Houbrechts, Nele ; Lambert, Didier ; Verbruggen, Alfons M. ; Van Laere, Koen ; Bormans, Guy M.. Synthesis and biological evaluation of carbon-11-and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging. In: Nuclear Medicine and Biology, Vol. 36, no. 4, p. 455-465 (2009). doi:10.1016/j.nucmedbio.2009.01.009.
Matuszak, Nicolas ; Muccioli, Giulio ; Labar, Geoffray ; Lambert, Didier. Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. In: Journal of Medicinal Chemistry, Vol. 52, no. 23, p. 7410-7420 (2009). doi:10.1021/jm900461w.
Wyffels, Leonie ; Muccioli, Giulio ; De Bruyne, Sylvie ; Moerman, Lieselotte ; Sambre, Johan ; Lambert, Didier ; De Vos, Filip. Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain. In: Journal of Medicinal Chemistry, Vol. 52, no. 15, p. 4613-4622 (2009). doi:10.1021/jm900324e.
Urbach, Allan ; Muccioli, Giulio ; Stern, Eric ; Lambert, Didier ; Marchand-Brynaert, Jacqueline. 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors.. In: Bioorganic & Medicinal Chemistry Letters, Vol. 18, no. 14, p. 4163-4167 (2008). doi:10.1016/j.bmcl.2008.05.081.
Muccioli, Giulio ; Stella, Nephi. An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brain. In: Analytical Biochemistry, Vol. 373, no.2, p. 220-228 (2008). doi:10.1016/j.ab.2007.09.030.
Muccioli, Giulio ; Labar, Geoffray ; Lambert, Didier. CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. In: ChemBioChem : a European journal of chemical biology, Vol. 9, no. 16, p. 2704-2710 (2008). doi:10.1002/cbic.200800428.
Gallienne, Estelle ; Muccioli, Giulio ; Lambert, Didier ; Shipman, Michael. Microwave-assisted four-component reaction for the synthesis of a monothiohydantoin inhibitor of a fatty acid amide hydrolase. In: Tetrahedron Letters, Vol. 49, no. 46, p. 6495-6497 (2008). doi:10.1016/j.tetlet.2008.08.100.
Hoet, Sara ; Pieters, Luc ; Muccioli, Giulio ; Habib Jiwan, Jean-Louis ; Opperdoes, Frederik ; Quetin-Leclercq, Joëlle. Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.. In: Journal of Natural Products, Vol. 70, no. 8, p. 1360-1363 (2007). doi:10.1021/np070038q.
Muccioli, Giulio. Blocking the cannabinoid receptors: Drug candidates and therapeutic promises. In: Chemistry & Biodiversity, Vol. 4, no. 8, p. 1805-1827 (2007). doi:10.1002/cbdv.200790153.
Labar, Geoffray ; Bauvois, Cedric ; Muccioli, Giulio ; Wouters, Johan ; Lambert, Didier. Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. In: ChemBioChem, Vol. 8, no. 11, p. 1293-1297 (2007). doi:10.1002/cbic.200700139.
Lambert, Didier ; Muccioli, Giulio. Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players.. In: Current opinion in clinical nutrition and metabolic care, Vol. 10, no. 6, p. 735-744 (2007). doi:10.1097/MCO.0b013e3282f00061.
Muccioli, Giulio ; Xu, Cong ; Odah, Emma ; Cudaback, Eiron ; Antonio Cisneros, Jose ; Lambert, Didier ; Lopez Rodriguez, Maria Luz ; Bajjalieh, Sandra ; Stella, Nephi. Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells. In: The Journal of Neuroscience, Vol. 27, no. 11, p. 2883-9 (2007). doi:10.1523/JNEUROSCI.4830-06.2007.
Stern, Eric ; Muccioli, Giulio ; Bosier, Barbara ; Hamtiaux, Laurie ; Millet, Regis ; Poupaert, Jacques ; Henichart, Jean-Pierre ; Depreux, Patrick ; Goossens, Jean-Francois ; Lambert, Didier. Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: Consequences in receptor affinity and functionality. In: Journal of Medicinal Chemistry, Vol. 50, no. 22, p. 5471-84 (2007). doi:10.1021/jm070387h.
Philip, Ashok E. ; Poupaert, Jacques ; Cheve, Gwenael ; Muccioli, Giulio ; Lambert, Didier ; McCurdy, Christopher R.. Structure-activity relationship of phenytoinergic antiepileptic drugs related to ameltolide. In: Medicinal Chemistry Research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, Vol. 16, no. 3, p. 130-135 (2007). doi:10.1007/s00044-007-9016-9.
Michaux, Catherine ; Muccioli, Giulio ; Lambert, Didier ; Wouters, Johan. Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: comparison with two original compounds, OL-92 and JP104. In: Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 16, no. 18, p. 4772-4776 (2006). doi:10.1016/j.bmcl.2006.06.087.
Muccioli, Giulio ; Lambert, Didier. Latest advances in cannabinoid receptor antagonists and inverse agonists. In: Expert Opinion on Therapeutic Patents, Vol. 16, no. 10, p. 1405-1423 (2006). doi:10.1517/13543776.16.10.1405.
Stern, Eric ; Muccioli, Giulio ; Millet, R ; Goossens, JF ; Farce, A ; Chavatte, P ; Poupaert, Jacques ; Lambert, Didier ; Depreux, P. ; Hénichart, Jean-Pierre. Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: Synthesis, pharmacological properties and molecular modeling. In: Journal of Medicinal Chemistry, Vol. 49, no. 1, p. 70-79 (2006). doi:10.1021/jm050467q.
Muccioli, Giulio ; Fazio, Nicola ; Scriba, Gerhard K E ; Poppitz, Wolfgang ; Cannata, Fabio ; Poupaert, Jacques ; Wouters, Johan ; Lambert, Didier. Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates.. In: Journal of Medicinal Chemistry, Vol. 49, no. 1, p. 417-425 (2006). doi:10.1021/jm050977k.
Muccioli, Giulio ; Wouters, Johan ; Charlier, Caroline ; Scriba, Gerhard K E ; Pizza, Teresa ; Di Pace, Pierluigi ; De Martino, Paolo ; Poppitz, Wolfgang ; Poupaert, Jacques ; Lambert, Didier. Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists.. In: Journal of medicinal chemistry, Vol. 49, no. 3, p. 872-82 (2006). doi:10.1021/jm050484f.
Muccioli, Giulio ; Wouters, Johan ; Scriba, Gerhard K E ; Poppitz, Wolfgang ; Poupaert, Jacques ; Lambert, Didier. 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.. In: Journal of medicinal chemistry, Vol. 48, no. 23, p. 7486-90 (2005). doi:10.1021/jm0503906.
Muccioli, Giulio ; Lambert, Didier. Current knowledge on the antagonists and inverse agonists of cannabinoid receptors.. In: Current medicinal chemistry, Vol. 12, no. 12, p. 1361-94 (2005). doi:10.2174/0929867054020891.
Gbaguidi, F. ; Muccioli, Giulio ; Accrombessi, Georges C. ; Moudachirou, M. ; Quetin-Leclercq, Joëlle. Densitometric HPTLC quantification of 2-azaanthraquinone isolated from Mitracarpus scaber and antimicrobial activity against Dermatophilus congolensis. In: Journal of Planar Chromatography - Modern TLC, Vol. 18, no. 105, p. 377-379 (2005). doi:10.1556/JPC.18.2005.5.8.
Muccioli, Giulio ; Martin, Diana ; Scriba, Gerhard K E ; Poppitz, Wolfgang ; Poupaert, Jacques ; Wouters, Johan ; Lambert, Didier. Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation.. In: Journal of medicinal chemistry, Vol. 48, no. 7, p. 2509-17 (2005). doi:10.1021/jm049263k.
Govaerts, Sophie ; Muccioli, Giulio ; Hermans, Emmanuel ; Lambert, Didier. Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors.. In: European Journal of Pharmacology, Vol. 495, no. 1, p. 43-53 (2004). doi:10.1016/j.ejphar.2004.05.023.
Muccioli, Giulio ; Poupaert, Jacques ; Wouters, Johan ; Norberg, Bernadette ; Poppitz, Wolfgang ; Scriba, Gerhard K. E. ; Lambert, Didier. A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins. In: Tetrahedron, Vol. 59, no. 8, p. 1301-1307 (2003). doi:10.1016/S0040-4020(03)00033-4.
Muccioli, Giulio ; Wouters, Johan ; Poupaert, Jacques ; Norberg, Bernadette ; Poppitz, Wolfgang ; Scriba, Gerhard K E ; Lambert, Didier. Versatile access to benzhydryl-phenylureas through an unexpected rearrangement during microwave-enhanced synthesis of hydantoins.. In: Organic letters, Vol. 5, no. 20, p. 3599-602 (2003). doi:10.1021/ol035282x.