Adipokines in health and diseases
Adipose tissue secretes adipokines, which play central roles in energy and vascular homeostasis as well as in immunity. Deregulation of these adipokines triggers the development of a low-grade pro-inflammatory state, which is considered to build the common soil for the development of obesity-linked disorders such as insulin resistance, type 2 diabetes and atherosclerosis, which are components of the metabolic syndrome
Resetting the immunological balance in adipose tissue may be a crucial approach for the future management of this syndrome. Adiponectin (ApN), which is decreased in the metabolic syndrome, is a potent enhancer of insulin action and fatty acid oxidation. Recently, this adipokine has also emerged as a master regulator of inflammation/immunity in various tissues, including adipose tissue, its own production site. ApN also turns out to be also be a potent anti-inflammatory hormone in skeletal muscle.
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Publications 2017-2018
Lecompte S, Abou-Samra M, Boursereau R, Noel L, and Brichard SM (2017) Skeletal muscle secretome in Duchenne muscular dystrophy: a pivotal anti-inflammatory role of adiponectin. Cell Mol Life Sci 74: 2487-2501
Boursereau R, Abou-Samra M, Lecompte S, Noel L, Brichard SM (2017) New targets to alleviate skeletal muscle inflammation: role of microRNAs regulated by adiponectin. Sci Rep 7: 43437
Abou-Samra M, Boursereau R, Lecompte S, Noel L, Brichard SM (2017) Potential Therapeutic Action of Adiponectin in Duchenne Muscular Dystrophy. Am J Pathol 187: 1577-1585
Boursereau R, Abou-Samra M, Lecompte S, Noel L, Brichard SM (2018) Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy. BMC Biol. 2018 Mar 20;16(1):33