小瓢虫传媒

Module 1 鈥� Introduction/basics principles of Toxicology :
Completed in 2019

• Dose/exposure
• Tools in toxicology
  • In vitro experimental toxicology
  • In vivo experimental toxicology
  • Human toxicology
  • Environmental toxicology
• Target organs/systems of toxicity through practical exercises

Module 3 鈥� Regulatory Toxicology of Chemicals:
Completed in 2019

• Introduction
• Hazard identification and characterization of the dose-response
• Hazard identification and communication
• Exposure assessment
• Risk Management: main principles and hierarchy of risk management measures
• Examples of frameworks
• Regulatory Toxicology and society

Module 4 鈥� In vitro toxicology (in collaboration with )
25-30 October 2020

• European legislative framework and international guidelines for in vitro toxicity testing of chemicals.
• Use and validation of 3R-alternative methods in Europe.
• In vitro methods for assessing cytotoxicity, skin sensitization, skin/eye irritation/corrosion, immunotoxicity, genotoxicity, carcinogenicity and developmental toxicity.
• Development and application of cell lines, organ-specific models, tridimensional and reconstructed models, bioreactors and stem cell models in in vitro toxicology.
• Use of 鈥渙mics鈥�-based methods in in vitro toxicology.
• Good in vitro method practices/good cell culture practice.
• In vitro kinetics and in vitro-in vivo extrapolation.
• In vitro aspects of pathway-based toxicology.
• Non-animal testing technologies and strategies used for chemical hazard and
• risk assessment in Europe.
• Hands-on training on skin and eye irritation testing in vitro.